Monday, February 4, 2013

Get up more traffic to your website through classified submission ...


Starting a business is not as easy as it looks. Should be taken into account a variety of factors, and is an important aspect of this promotion. It's just the right advertising and marketing to attract customers is impossible without. In the early days by posting ads in newspapers and magazines to promote a business. However, as time passed by, many companies online. The internet is definitely one of the best ways to promote your company to a large crowd is one? Millions of users surf the internet at the end. There are two main benefits of online visibility and link popularity is promotions. This is where the image is classified as a paid service.

For a large number of free classified websites that are offering these services at affordable prices. Visit these sites daily to look for products and services based on people. Presented a largely classified, helps to increase your online presence. ?To better serve both online and offline storage. This service uses new and innovative tools to make sure that your website receives maximum attention online. For webmasters to promote their products and services allows for a wider audience. There are many benefits associated with the use of this service. To start, your brand online visibility to the target audience. You also get a free one-way links.

Classified Submission services are provided by professionals and experts. They offer services according to your needs and are knowledgeable and experienced. It shares the best free classified sites or websites that offer free listings on your website is submitted. This submission is done manually, this process helps to create search engine friendly. Because many service providers, it is highly recommended that you subscribe to the quality of services provided by the post as you know, read reviews will help. Submission Classified addition, there is also a deep link directory submission, referral web properties, squidoo lens creation, blog posts, article submission, and other services as others that can help increase online visibility. For more information about these services, please take a look at the website.

Source: http://bukisatraffic.blogspot.com/2013/02/get-up-more-traffic-to-your-website.html

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Find Mobile ? Buzz

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This entry was posted on Sunday, February 3rd, 2013 at 3:39 am and is filed under buzz. You can follow any comments to this entry through the RSS 2.0 feed. Responses are currently closed, but you can trackback.

Source: http://buzz.themultisiteblog.com/find-mobile/

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Sunday, February 3, 2013

Gene therapy: Editing out genetic damage

Jan. 31, 2013 ? New design guidelines from researchers in Singapore simplify the development of targeted therapies for muscular dystrophy and other diseases.

The dystrophin protein offers critical support to muscle fibers. Mutations affecting dystrophin's expression cause the muscle-wasting disease muscular dystrophy. In Duchenne muscular dystrophy (DMD), these mutations take the form of small sequence changes that make much of the dystrophin gene (DMD) untranslatable, yielding nonfunctional protein or no protein at all.

Therapies based on a strategy known as 'exon skipping' could undo the damage from these mutations. Development of such treatments is set to accelerate, thanks to research by a team led by Keng Boon Wee of the A*STAR Institute of High Performance Computing and Zacharias Pramono of the National Skin Centre in Singapore.

Proteins are translated from messenger RNA transcripts of genes; however, only certain RNA regions -- known as exons -- actually encode protein, and these are enzymatically spliced together prior to translation. Several clinical studies have demonstrated that small 'antisense oligonucleotide' (AON) molecules that bind mutated DMD exons can induce elimination of those defective exons during splicing, yielding shorter but largely functional versions of dystrophin. "We are cautiously optimistic that AON-induced exon skipping could be the first effective therapy for DMD patients," says Wee.

Unfortunately, DMD arises from many different mutations, and targeted AON design remains a time-consuming, trial-and-error process. To address this challenge, Wee and Pramono sought to define the characteristics of AONs that efficiently promote exon-skipping. They used computational analysis to zoom in on exonic sequences that coordinate splicing. They also identified regions of suitable length within dystrophin RNA transcripts that span these sequences and would be accessible to AONs in living cells.

The researchers thus derived a set of guidelines enabling them to effectively design AONs that targeted nine different exons affected in DMD patients. For each exon, at least one AON proved capable of boosting dystrophin expression to clinically relevant thresholds in cultured muscle cells (see image). "Our proposed set of factors resulted in a reasonable success rate of designing efficient AONs -- 61% versus 38% using semi-empirical methods," says Wee. Clinical studies have already demonstrated the promise of efficient exon skipping in treating DMD patients.

Wee notes that other diseases arising from abnormal RNA processing could also benefit from this approach. However, his team is also exploring this method as a general strategy to abort production of disease-causing proteins in cancer and other conditions. "In contrast to small-molecule inhibitor drugs that can target only about 10% of the human genome, this approach could downregulate most human genes," Wee says.

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Story Source:

The above story is reprinted from materials provided by The Agency for Science, Technology and Research (A*STAR).

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Pramono, Z. A. D., Wee, K. B., Wang, J. L., Chen, Y. J., Xiong, Q. B. et al. A prospective study in the rational design of efficient antisense oligonucleotides for exon skipping in the DMD gene. Human Gene Therapy, 2012 DOI: 10.1089/hum.2011.205

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/p2_gTFzETgw/130203145430.htm

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Iran's New Indigenous Qaher 313' - Business Insider

The Aviationist

Iran yesterday revealed its most recent indigenous fighter jet ? the ?Qaher 313?.?The prototype Q-313 was presented to?President Mahmoud Ahmadinejad, as a ceremonial gift during the country's Ten-Day Dawn celebration. The festivities commemorate the 1979 revolution when the U.S. embassy in Tehran taken by force.?

In the previous days, the Iranian Defense Minister Brigadier General Ahmad Vahidi had said, ?The aircraft will be different from the other fighter jets Iran has already made.?

Indeed, based on the first photographs released by the FARS News Agency, the new stealthy jet has a peculiar design. It features hard edges and those distinctive edges and angle of the U.S.?F-22?and the twin tail shape much similar to that of the?F-35 Lightning II.

The Q-313 has large, seemingly fixed canards, and little wings whose external section is canted downward, while the?canopy material is at least odd (based on its transparency, it looks like Plexiglas or something like that).

The cockpit seems basic (a bit too much for a modern plane ? note the lack of wiring?behind the front panel).

The air intakes are extremely small whereas the engine section lacks any kind of nozzle ??above all ? the aircraft is way too small. Click here for more pictures at the Aviationist >

Putting aside the Qaher's implausible aerodynamics and Hollywood sheen, last week's announcement of a coming new domestic fighter was not insignificant given the Iranian air force has no more than a few dozen strike aircraft.

Most of those it inherited from the prior regime during the 1979 revolution. That regime change, involving a huge U.S. hostage situation, made it far more difficult to maintain the country's then-new fleet of American F-14s.

Tehran has a domestically built fighter already. At least a handful have been sighted during air shows and displays, but this new model is a drastic change in design and ability.

Of course, Iran is famous for building models and systems it never intends to fly, but if this is an actual prototype it may be designed to fill a uniquely Iranian requirement.

Air dominance against the nearly 200 aircraft of the U.S. Fifth Fleet out of Bahrain isn't a realistic goal for Tehran. What it would look to do in any open engagement with the U.S. would be to overwhelm American surface ships with small, high-speed boats, and missiles of its own.?

Those boats would immediately be set upon by a fleet of U.S. helicopters and fixed wing aircraft. Most naval experts are quick to point out that a fight between a helo' and a boat generally isn't much of a fight at all. Un-distracted helicopters have immense advantages, but once they start taking fire or need to react to other airborne attacks, that changes.

Perhaps Iran isn't imagining a fleet of stealthy fighter/bombers, based on some design similar to this new display, but a few dozen single seat craft with an array of missiles, a couple guns, and the ability to fly low and slow over the Gulf.

A string of planes to compliment the one military project they've been working hardest over the last decade, but rarely ever mention. That plane would be a handy addition to cover the?Bradstone based speed boat, they believe can take on the Fifth Fleet and bring down the U.S. Navy.

While Iran does have a few HESA Shahed light attack/recon helicopters, they're

?modestly armed and have a limited range of a couple hundred miles.

Iran's other domestically produced jet, the Saeqeh fighter?is?designed to engage other fighters in mid-air combat also not a practical choice against the might of the U.S. Fleet.

A Qaher variation against the Bradstone would fill a niche, but is obviously pure speculation. But speculating has some value when examining Iran's military projects because like most countries, the weapons Tehran speaks of the least seem to mean the most.?

This couldn't be more true than in the case of the?ill-gotten Bradstone and Iran's blossoming missile inventory that's about as extensive and diverse as it is deadly and proven.

We'll be sure to follow with any additional Qaher updates.

SEE ALSO:?THE BONEYARD: Where Air Force birds go to die >

SEE ALSO:??The Military & Defense Facebook page for updates >

Source: http://www.businessinsider.com/irans-new-indigenous-fighter-qaher-313-david-cenciotti-2013-2

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Friday, February 1, 2013

25 die in Mexico oil company office building blast

An emergency responder carries a piece of concrete as emergency workers and firefighter dig for survivor at the site on an explosion at an adjacent building to the executive tower of Mexico's state-owned oil company PEMEX, in Mexico City, Thursday Jan. 31, 2013. The explosion killed more than 10 people and injured some 80 as it heavily damaged three floors of the building, sending hundreds into the streets and a large plume of smoke over the skyline. (AP Photo/Eduardo Verdugo)

An emergency responder carries a piece of concrete as emergency workers and firefighter dig for survivor at the site on an explosion at an adjacent building to the executive tower of Mexico's state-owned oil company PEMEX, in Mexico City, Thursday Jan. 31, 2013. The explosion killed more than 10 people and injured some 80 as it heavily damaged three floors of the building, sending hundreds into the streets and a large plume of smoke over the skyline. (AP Photo/Eduardo Verdugo)

An injured person is carried into an ambulance after an explosion at an adjacent building to the executive tower of Mexico's state-owned oil company PEMEX, in Mexico City, Thursday Jan. 31, 2013. An explosion at the main headquarters of Mexico's state-owned oil company in the capital killed more than 10 people and injured some 80 as it heavily damaged three floors of the building, sending hundreds into the streets and a large plume of smoke over the skyline. (AP Photo/Eduardo Verdugo)

Rescue workers, firefighters and military search for survivors at the site of an explosion in a building at Mexico's state-owned oil company PEMEX complex, in Mexico City, Thursday Jan. 31, 2013. The explosion killed more than 10 people and injured some 80 as it heavily damaged three floors of the building. According to civil protection and local media some people remained trapped in the debris from the explosion, which occurred in the basement of an administrative building next to the iconic, 52-story tower of Petroleos Mexicanos, or PEMEX. (AP Photo/Eduardo Verdugo)

Rescue workers, firefighters and military search for survivors at the site of an explosion in a building at Mexico's state-owned oil company PEMEX complex, in Mexico City, Thursday Jan. 31, 2013. The explosion killed more than 10 people and injured some 80 as it heavily damaged three floors of the building. According to civil protection and local media some people remained trapped in the debris from the explosion, which occurred in the basement of an administrative building next to the iconic, 52-story tower of Petroleos Mexicanos, or PEMEX. (AP Photo/Eduardo Verdugo)

An emergency responder carries a piece of concrete as emergency workers and firefighter dig for survivor at the site on an explosion at an adjacent building to the executive tower of Mexico's state-owned oil company PEMEX, in Mexico City, Thursday Jan. 31, 2013. The explosion killed more than 10 people and injured some 80 as it heavily damaged three floors of the building, sending hundreds into the streets and a large plume of smoke over the skyline. (AP Photo/Eduardo Verdugo)

MEXICO CITY (AP) ? Rescuers searched for survivors and authorities promised a thorough investigation after an office building blast killed 25 people and injured 101 at the headquarters of Mexico's state-owned oil company, Petroleos Mexicanos.

The cause of the basement explosion in an administrative building next to the iconic, 51-story Pemex tower in Mexico City remained a mystery early Friday, with President Enrique Pena Nieto urging people not to speculate. Theories ranged from an electrical fire to an air conditioning problem to a possible attack.

"We have no conclusive report on the reason," Pena Nieto told reporters. "We will work to get to the bottom of the investigation to find out, first, what happened ... and if there are people responsible in this case, that we apply the full weight of the law against them."

Some 46 people remained hospitalized after the Thursday afternoon blast, some gravely injured and others with cuts, fractures and burns. Authorities said the dead were 17 women and eight men.

More than 500 firefighters, soldiers and rescue workers dug through chunks of concrete with dogs, trucks and a Pemex crane.

Interior Minister Miguel Osorio Chong said it was uncertain if any of the roughly 10,000 people who work in the five-building headquarters were still trapped, but that the search would continue. The explosion occurred at about 3:45 p.m., just as the administrative shift was about to end. It hit the basement and first two floors, which rescuers said all collapsed onto each other.

"There is a lot of risk," rescuer German Vazquez Garcia said of working on the site.

Pemex first said it had evacuated the tower and 14-story administrative building because of a problem with the electrical system. The company later tweeted that the Attorney General's Office was investigating the explosion.

Ana Vargas Palacio was distraught as she searched for her missing husband, Daniel Garcia Garcia, 36, who works in the building where the explosion occurred. She said she last talked to him a couple hours earlier.

"I called his phone many times, but a young man answered and told me he found the phone in the debris," Vargas said. The two have an 11-year-old daughter. His mother, Gloria Garcia Castaneda, collapsed on a friend's arm, crying "My son. My son."

Gabriela Espinoza, 50, a Pemex secretary for 29 years, was on the second floor of the tower when she said she heard two loud explosions and a third smaller one.

"There was a very loud roar. It was very ugly," she said.

Espinoza's co-worker, Tomas Rivera, 32, worked on the ground floor where the explosion occurred and said the force knocked him to the basement, fracturing his wrist and jaw. The injured were taken to two Pemex hospitals and other facilities, including the Red Cross hospital in the Polanco neighborhood near the oil company's office headquarters, where relatives huddled in the waiting room for news of their loved ones. Some walked out of meetings with the hospital social worker joyous, while others came out crying.

"We were talking and all of sudden we heard an explosion with white smoke and glass falling from the windows," said Maria Concepcion Andrade, 42, who lives on the same block as the Pemex building. "People started running from the building covered in dust. A lot of pieces were flying."

Streets surrounding the building were closed as evacuees wandered around, and rescue crews loaded the injured into ambulances.

Pemex, created as a state-owned company in 1938, has nearly 150,000 employees and in 2011 produced about 2.5 million barrels of crude oil a day, according to its website, with $111 billion in sales. Pena Nieto, who took office in December, has made Pemex reform the center of his platform, with a plan to pump new investment into a company whose profits feed much of Mexico's federal budget, but which has fallen behind other oil companies in production, technology and exploration.

Shortly before the explosion, Operations Director Carlos Murrieta reported via Twitter that the company had reduced its accident rate in recent years. Most Pemex accidents have occurred at pipeline and refinery installations.

A fire at a pipeline metering center in northeast Mexico near the Texas border killed 30 workers in September, the largest-single toll in at least a decade for the company.

______

Associated Press writers Adriana Gomez Licon and Katherine Corcoran contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-02-01-Mexico-Pemex-Explosion/id-11565de0e9a44d0fa9df8566db60a483

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Video: Feeling Rich at Dow 14,000?

Sorry, Readability was unable to parse this page for content.

Source: http://video.msnbc.msn.com/cnbc/50669670/

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At Exhib? we have produced many award winning custom exhibits. However, we don't design to win awards. We design to meet your specific show objectives. From the start we analyze your product, your market position and review your sales and marketing goals to produce custom trade show exhibits that will excel. We carefully review your show schedule, logistical requirements, traffic flow and work hard to create a sales display environment that has impact and is an effective marketing tool.

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Source: http://www.exhibe.com/custom-exhibits.htm

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