Promising compound restores memory loss and reverses symptoms of Alzheimer's in mice

Jan. 2, 2013 ? A new ray of hope has broken through the clouded outcomes associated with Alzheimer's disease. A new research report published in January 2013 print issue of the FASEB Journal by scientists from the National Institutes of Health shows that when a molecule called TFP5 is injected into mice with disease that is the equivalent of human Alzheimer's, symptoms are reversed and memory is restored -- without obvious toxic side effects.

"We hope that clinical trial studies in AD patients should yield an extended and a better quality of life as observed in mice upon TFP5 treatment," said Harish C. Pant, Ph.D., a senior researcher involved in the work from the Laboratory of Neurochemistry at the National Institute of Neurological Disorders at Stroke at the National Institutes of Health in Bethesda, MD. "Therefore, we suggest that TFP5 should be an effective therapeutic compound."

To make this discovery, Pant and colleagues used mice with a disease considered the equivalent of Alzheimer's. One set of these mice were injected with the small molecule TFP5, while the other was injected with saline as placebo. The mice, after a series of intraperitoneal injections of TFP5, displayed a substantial reduction in the various disease symptoms along with restoration of memory loss. In addition, the mice receiving TFP5 injections experienced no weight loss, neurological stress (anxiety) or signs of toxicity. The disease in the placebo mice, however, progressed normally as expected. TFP5 was derived from the regulator of a key brain enzyme, called Cdk5. The over activation of Cdk5 is implicated in the formation of plaques and tangles, the major hallmark of Alzheimer's disease.

"The next step is to find out if this molecule can have the same effects in people, and if not, to find out which molecule will," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "Now that we know that we can target the basic molecular defects in Alzheimer's disease, we can hope for treatments far better -- and more specific -- than anything we have today."

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The above story is reprinted from materials provided by Federation of American Societies for Experimental Biology, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. V. Shukla, Y.-L. Zheng, S. K. Mishra, N. D. Amin, J. Steiner, P. Grant, S. Kesavapany, H. C. Pant. A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice. The FASEB Journal, 2012; 27 (1): 174 DOI: 10.1096/fj.12-217497

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/BdOiO-r1N-s/130102140535.htm

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1950s singing star Patti Page dies at 85

By Gael Fashingbauer Cooper , TODAY

Singer Patti Page, whose smooth alto voice made hits of "How Much Is That Doggie in the Window?", "Tennessee Waltz" and "Old Cape Cod," has died at 85, her manager confirmed to NBC News. She had a seven-decade musical career and sold more than 100 million records. Though some of her hits were considered novelty songs, she continued to perform into the 2000s, and briefly dabbled in television.

Page died at the Seacrest Village nursing home in Encinitas, Calif.

The Grammy Awards will honor Page, along with other artists -- including Carole King and the late Ravi Shankar -- with lifetime achievement awards at the ceremony Feb. 10.

Born Clara Ann Fowler in Oklahoma, she was the second of 11 children and told the New York Times she remembered living without electricity. She began singing on local radio as a teenager and was given her stage name because a sponsor of that show was the Page Milk Company.

The biggest hit of her career, "Tennessee Waltz," about an old friend who steals the singer's lover while dancing, was No.1 for nine weeks in 1950 and 1951 and is one of seven official state songs for Tennessee.

"How Much Is That Doggie In the Window?" was No.1 for eight weeks in 1953. In 2009, Page recorded a version using the same tune and different lyrics, called "Do You See That Doggie in the Shelter?" and gave the rights to the song to the Humane Society of the United States.

"The original song asks the question: 'How much is that doggie in the window?' " Page told the Humane Society. "Today, the answer is 'too much.' And I don't just mean the price tag on the puppies in pet stores. The real cost is in the suffering of the mother dogs back at the puppy mill. That's where most pet store puppies come from. And that kind of cruelty is too high a price to pay."

She also sang the theme to the 1964 Bette Davis thriller "Hush, Hush, Sweet Charlotte," which reached No. 8 on the charts.

Page's other hits included "Old Cape Cod," "With My Eyes Open Wide, I'm Dreaming" and "I Went to Your Wedding." Her friends included Rosemary Clooney and Elvis Presley, and she attended the "Ed Sullivan Show" on the famed 1964 night when the Beatles were introduced to America. (Page thought they were "cute kids," The New York Times reported.)

She also had numerous television specials and series, including "The Patti Page Show," which ran for just one season in 1955-1956, and "The Patti Page Oldsmobile Show" in 1958-1959.

"What I like about singing is that, for me, it's a substitute for the psychiatrist's couch," Page told The New York Times in 2003. "I can tell it all in song: pathos, gladness, love, joy, unhappiness. Each song, you're telling a story and acting."

Her music was sometimes criticized for its simplicity, but Page knew what the audiences of the 1950s wanted.

"My music was called plastic, antiseptic, placid," she told The Times. "It was only five or so years after the war, a different time. A simpler time. The music was simpler, too."

She was married three times and had a son and a daughter.

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Source: http://todayentertainment.today.com/_news/2013/01/02/16303134-patti-page-dies-at-85-sang-tennessee-waltz-how-much-is-that-doggie-in-the-window?lite

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This 'Looper' Deleted Scene Is Better Than Most Scenes In Other Movies

You can now own Rian Johnson's latest film "Looper," the noir-inspired time travel flick that blew our minds and made its way onto our ten best list, on Blu-ray and DVD, and if you haven't picked up the disc yet, you are missing out. While we hope you've seen "Looper" by now (because it kicks [...]

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Kris Allen Breaks Arm In New Year's Car Accident, Announces Fatherhood

'Yes I got in a really bad wreck tonight and yes I'm having a lil baby,' the season eight 'American Idol' winner wrote.
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These Spiders Are Frightening and Beautiful At the Same Time

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Adam Levin: Welcome to the Fiscal Blip. Demand More in 2013

In what Democrat pundits are trying to spin as white-flag politics today, it would appear a deal is imminent and each side will spin the merits, or lack thereof, for the purposes of the overblown shadow play that we've witnessed around the so-called "fiscal cliff." The difference between right and left isn't much when you consider the kind of money that people are making these days in the more rapacious sectors of our economy. The real problem here is that people are calling this a done deal.

Also: Why does something of this import have to go until the final minute of the final hour of the final day only to meet with a lack of time (read: will) of the House so it has to wait until after the deadline has passed and we "theoretically" fall off the cliff?

At least during the debates about the Credit Card Reform Act and Dodd-Frank, the opposing sides were the citizenry vs. the financial corporations. What we're dealing with here is harder to define. That's because the fiscal cliff is in no small way a histrionic and hysterical method of framing budgetary issues by way of bully non-choices: want a weakened military? higher taxes for the middle class? How about a double-dip recession? While we're at it, when did you stop beating your partner? The fiscal cliff is unsolvable by design.

The misguided (dys-principled?) compromise of 2011 that created it must be seen for the train wreck of congressional leadership that allowed it to happen. In no small measure, we're in this mess not just because of a "crisis" around debt or Medicare. We are in this mess because of an identity crisis. Too many lawmakers have gotten elected with too much corporate backing, and as a result a board room mentality has metastasized throughout a budget process that theoretically depends on the checks and balances of power that allegedly define the collective "process" that is our elected representation in Washington. So in one way, we're to blame by voting for the best corporate-sponsored marketing campaign.

The fiscal cliff is finally about banks, desperate to maintain the unsustainable profits created by the mortgage boom, selling mortgages to people who could not afford them. It's about balloon payments and adjustable interest rates, time bombs disguised as mortgages. It's as if Donald Trump secretly took over the banking industry -- and as a result a casino culture that is all flash and no substance prevails. The fiscal cliff is the bully's threat -- and the above financial FUBAR is what the bully is trying to protect. It is not about whether the middle class tops out at $250,000 a year or $450,000 since most members of the middle class would be euphoric to earn such income.

Citizens United is not the moment we placed corporations' rights over those of actual human beings. The Supreme Court's decision capped a decade-long process of corporate empowerment. Now, these same corporate interests (through their purchased representatives in Congress) have manufactured a bogus fiscal cliff in the cynical hope that they can foist even more of responsibility off their ledgers and onto the backs of America's non-rich.

The "cliff" is a metaphorical illusion -- a political construct. Forget the narrow confines of its binary problem (tax breaks for the rich vs. continuing insurance for the unemployed), a political problem allows for a creative, political solution. We should use this fake, ginned-up "crisis" to our advantage and solve the real problems faced by real Americans. We should demand that that happens.

It could be that the answer to what ails America economically is rewarding companies that operate with a healthy reality principle like the Triple Bottom Line system of accounting where decisions are predicated by the "Three P's:" Profit, People and Planet. Whatever we do, it's time for the country to age out of the fake value, paper-billionaire age and start looking for ways to create real value for investors, workers and the nation.

As the novelist Edward Abbey famously wrote, "Growth for the sake of growth is the ideology of a cancer cell." We've all spent too much time in the casino culture that created the fiscal cliff to simply walk away from it unscathed. It's the way of the house, which makes a bundle whether you lose money or not. The fiscal cliff is a scary way of framing the fact that we need a mid-course correction in this country with regard to the way we do business in Washington and everywhere else in the country.

One definition of insanity is doing the same thing over and over expecting a different result. It seems sane to refuse to have the same corporations that caused this mess (or the lawmakers who represent them exclusively at the expense of taxpayers) dictate our options for solving it. It's time to call the bluff.

We did it on the Credit Card Reform Act and Dodd Frank. We elected Elizabeth Warren after she was unceremoniously driven out of Washington by anti-consumer interests. America has a Consumer Financial Protection Bureau despite the specific directives of the American Bankers' Association and the US Chamber of Commerce.

It can be done.

?

Follow Adam Levin on Twitter: www.twitter.com/Adam_K_Levin

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Source: http://www.huffingtonpost.com/adam-levin/welcome-to-the-fiscal-bli_b_2391029.html

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Alex Ovechkin and Maria Kirilenko: Engaged!

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