Friday, December 14, 2012

Too many antibiotics? Bacterial ecology that lives on humans has changed in last 100 years

Dec. 13, 2012 ? A University of Oklahoma-led study has demonstrated that ancient DNA can be used to understand ancient human microbiomes. The microbiomes from ancient people have broad reaching implications for understanding recent changes to human health, such as what good bacteria might have been lost as a result of our current abundant use of antibiotics and aseptic practices.

Cecil M. Lewis Jr., professor of anthropology in the OU College of Arts and Sciences and director of the OU Molecular Anthropology Laboratory, and Raul Tito, OU Research Associate, led the research study that analyzed microbiome data from ancient human fecal samples collected from three different archaeological sites in the Americas, each dating to over 1000 years ago. In addition, the team provided a new analysis of published data from two samples that reflect rare and extraordinary preservation: Otzi the Iceman and a soldier frozen for 93 years on a glacier.

"The results support the hypothesis that ancient human gut microbiomes are more similar to those of non-human primates and rural non-western communities than to those of people living a modern lifestyle in the United States," says Lewis. "From these data, the team concluded that the last 100 years has been a time of major change to the human gut microbiome in cosmopolitan areas."

"Dietary changes, as well as the widespread adoption of various aseptic and antibiotic practices have largely benefited modern humans, but many studies suggest there has been a cost, such as a recent increase in autoimmune related risks and other health states," states Lewis.

"We wish to reveal how this co-evolutionary relationship between humans and bacteria has changed, while providing the foundation for interventions to reconstruct what has been lost. One way to do this is to study remote communities and non-human primates. An alternative path is to look at ancient samples and see what they tell us," Lewis says.

"An argument can be made that remote traditional communities are not truly removed from modern human ecologies. They may receive milk or other food sources from the government, which could alter the microbial ecology of the community. Our evolutionary cousins, non-human primates are important to consider. However, the human-chimp common ancestor was over six million years ago, which is a lot of time for microbiomes to evolve distinct, human signatures."

Retrieving ancient human microbiome data is complementary to these studies. However, studying ancient microbiomes is not without problems. Assuming DNA preserves, there is also a problem with contamination and modification of ancient samples, both from the soil deposition, and from other sources, including the laboratory itself.

"In addition to laboratory controls in our study, we use an exciting new quantitative approach called source tracking developed by Dan Knights from Rob Knight's Laboratory at the University of Colorado in Boulder, which can estimate how much of the ancient microbiome data is consistent with the human gut, rather than other sources, such as soil," explains Lewis.

"We discovered that certain samples have excellent gut microbiome signatures, opening the door for deeper analyses of the ancient human gut, including a better understanding of the ancient humans themselves, such as learning more about their disease burdens, but also learning more about what has changed in our gut today."

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Story Source:

The above story is reprinted from materials provided by University of Oklahoma.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Raul Y. Tito, Dan Knights, Jessica Metcalf, Alexandra J. Obregon-Tito, Lauren Cleeland, Fares Najar, Bruce Roe, Karl Reinhard, Kristin Sobolik, Samuel Belknap, Morris Foster, Paul Spicer, Rob Knight, Cecil M. Lewis. Insights from Characterizing Extinct Human Gut Microbiomes. PLoS ONE, 2012; 7 (12): e51146 DOI: 10.1371/journal.pone.0051146

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/g-3PktpcVno/121213132546.htm

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Lethal stings from the Australian box jellyfish could be treated with zinc

Dec. 12, 2012 ? Box jellyfish of the Chironex species are among the most venomous animals in the world, capable of killing humans with their sting. Their venom, though, which kills by rapidly punching holes in human red blood cells, can be slowed down by administering zinc, according to research published December 12 in the open access journal PLOS ONE by Angel Yanagihara from the University of Hawaii and colleagues.

The researchers developed ways to extract venom from the jellyfish, and tested it on human blood and on mice. They found that the venom created pores in human red blood cells, making them leak large amounts of potassium, which causes cardiac arrest and death.

As Yanagihara elaborates, "For over 60 years researchers have sought to understand the horrifying speed and potency of the venom of the Australian box jellyfish, arguably the most venomous animal in the world. We have found that a previously disregarded hemolysin can cause an avalanche of reactions in cells. This includes an almost instantaneous, massive release of potassium that can cause acute cardiovascular collapse and death."

The authors treated the cells with a zinc compound which inhibits this process, and found that the treatment could slow the pore-forming process in cells, and increased survival times in the mice treated with the compound, zinc gluconate. The research suggests that the venom's capacity to increase potassium levels is what makes it so dangerous, and that rapid administration of zinc may be a potential life-saver in human sting victims.

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Story Source:

The above story is reprinted from materials provided by Public Library of Science.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Angel A. Yanagihara, Ralph V. Shohet. Cubozoan Venom-Induced Cardiovascular Collapse Is Caused by Hyperkalemia and Prevented by Zinc Gluconate in Mice. PLoS ONE, 2012; 7 (12): e51368 DOI: 10.1371/journal.pone.0051368

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/1k0UeEguVNU/121212205611.htm

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Aetna plans to join 15 exchanges under U.S. healthcare reform

NEW YORK (Reuters) - Aetna Inc, the third largest U.S. health insurer, said on Wednesday that by 2014 it expects to be part of about 15 healthcare exchanges being established under government reforms.

Aetna, one of the companies on the front lines of healthcare changes in the United States, told analysts and investors that it believes an increase in the number of customers from the new market places will likely contribute to its growth.

An estimated 30 million more people are expected to join the insured over the next decade because of the U.S. Patient Protection and Affordable Care Act of 2010. Millions of those will seek their health insurance through the exchanges.

States have until December 14 to decide whether they will participate in a state-based, federal or partnership exchange. About 18 states have said they will create their own state-based exchanges and 18 others plan to default to a federal exchange, according to the Kaiser Family Foundation, a non-profit health policy group.

The shift to exchanges is fundamentally changing the managed care business, Aetna executives said during Wednesday's meeting with analysts and investors.

"More and more consumers are going to be buying their healthcare, even if the employer-sponsored system survives," Chief Executive Officer Mark Bertolini said. "A lot of things that we do today are no longer necessary to the end buyer."

Aetna said profits will be helped by cost controls and growth of carefully managed care organizations -- networks of doctors that work together -- and expansion in government programs, such as Medicare for the elderly and Medicaid for the poor, and Aetna's pending purchase of Coventry Health Care Inc..

Aetna expects earnings of $5.40 per share in 2013, below analyst estimates of $5.52 per share according to ThomsonReuters I/B/E/S. It sees revenue growth of 9 percent in 2013.

Competitors such as UnitedHealth Group Inc and Cigna Corp also gave weaker than expected 2013 earnings outlooks during their year-end meetings with analysts and investors. Aetna shares rose about $1.96 to $46.43 in midday New York Stock Exchange trading.

Aetna, whose $5.6 billion acquisition of regional insurer Coventry is being looked at by antitrust regulators, said that it still expects the deal to close in the middle of next year. It said it has not run into any issues that are beyond its expectations.

Aetna Chief Financial Officer Joe Zubretsky said in an interview that Aetna had not factored the possibility of the United States going over the so-called fiscal cliff into its 2013 outlook. The "fiscal cliff" is a combination of mandatory spending cuts and tax increases that will go into effect at the beginning of next year if a deficit cutting resolution is not reached by U.S. lawmakers.

Aetna's outlook is based on a cautious view of the economy and one in which unemployment remains at about 7.5 percent and interest rate returns remain extremely low, the company said.

"We're pretty much assuming the cliff gets solved," Zubretsky said.

But he said the company is concerned and guarded against the possibility that it is not resolved. If that does happen, he said U.S. employees poised to lose their jobs and health insurance may increase use of medical services, or Aetna's large employer business may decrease as companies cut back on employees, both of which would likely hurt profits.

(Editing by Bill Berkrot and Grant McCool)

Source: http://news.yahoo.com/aetna-plans-join-15-exchanges-under-u-healthcare-192000274--finance.html

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Sao Paulo awarded Copa Sudamericana final

Associated Press Sports

updated 3:13 a.m. ET Dec. 13, 2012

SAO PAULO (AP) - The image of Brazilian soccer in the lead up to the 2014 World Cup took a hit Wednesday when the final of the Copa Sudamericana was abandoned after visiting club Tigre accused security officials of pulling guns and beating its players.

Sao Paulo was awarded the title when Tigre refused to take the field for the second half of Wednesday's second leg of the final. Sao Paulo was leading 2-0, with the first leg having ended scoreless.

Officials of the Argentine club said their players and staff were beaten by security officials in the dressing room area at halftime and guns were drawn. The trouble off the pitch followed scuffles between the teams at the end of the first half.

Nestor Gorosito, the coach of Tigre, declined to take his team back on the field for the second half. He said security officials pulled guns on his players while others clubbed players and team officials.

"They pulled two revolvers," he said, referring to unspecified security officials. "We're not going to play anymore."

The chaotic scenes in Sao Paulo, before a sellout crowd of 65,000 at Morumbi stadium, is sure to trouble FIFA - the governing body of world soccer - which already has been frustrated by slow preparations for the World Cup.

Most of FIFA's angst so far has been focused on getting stadiums and new infrastructure in place. Now security also looms as a concern for the World Cup, which will be played at 12 venues across the country.

Violence on and off the pitch still blights many matches in South America, with Brazil and Argentina particularly affected. For the World Cup, FIFA relies on local officials and police to enforce safety at the stadiums.

The Confederations Cup, a preparatory event for the World Cup featuring eight national teams, will be played next year at six venues in Brazil.

With the 2016 Summer Games slated for Rio de Janeiro, Olympic officials also are sure to review the incident.

The trouble at the Morumbi stemmed from confrontations between the teams following a first half in which the hosts had taken a 2-0 lead on goals from Lucas and Osvaldo.

It was unclear what happened in the dressing room area, but Argentine television showed what appeared to be blood-spattered walls. Argentine television also showed several Tigre staff members with bruises and bloody faces.

"Police entered and struck our players with clubs," Gorosito told Argentine television. "It was crazy. What happened was crazy."

Romer Osuna, a Bolivian official with CONMEBOL, South America's governing body of soccer, said Tigre players were afraid to return to the field.

"The Tigre people declined to play because they considered security was not good enough," Osuna told Fox Sports.

Referee Enrique Osses of Chile awarded the victory to Sao Paulo after waiting about 30 minutes for Tigre to retake the field.

Sao Paulo scored twice in five minutes in the first half - a left-footed drive from Lucas in the 23rd and a lobbing shot from the right wing by Osvaldo in the 28th.

Sao Paulo, one of Latin America's most famous clubs, is a three-time winner of the Copa Libertadores, South America's most prestigious club tournament. It has also won the Club World Cup once, and twice won the Intercontinental Cup, the predecessor to the Club World Cup.

This was the club's first Copa Sudamericana title.

Tigre was playing in its first international final and has never won the Argentine first-division title.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Source: http://nbcsports.msnbc.com/id/50184109/ns/sports-soccer/

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Thursday, December 13, 2012

One of you two gets sacked; you choose who

6 hrs.

You could call it the ?Hunger Games? approach to layoffs ? one that?s getting a big thumbs-down from workplace experts.

The Kansas City Star recently told two of its journalists,?Karen Dillon and Dawn Bormann,?that only one of them could keep her job --?and the employees themselves would have to decide who should leave the company, according to the media blog JimRomenesko.com.

Dillion?confirmed the report in an e-mail to NBC News, but did not provide any more details. The investigative reporter has worked for the Kansas City Star since 1991, according to her LinkedIn profile.

Bormann?did not answer an e-mail seeking comment. She reportedly?is leaving the company, according to KC Confidential, a blog that covers Kansas City issues.?

On Monday,?Mi-Ai Parrish, president and publisher of the Kansas City Star, announced in a memo to?staffers?a new round of layoffs -- the third since she joined the company in 2011,?according to MediaKC, a blog that covers media issues.

In a statement e-mailed to NBC News late Wednesday,?Parrish said the paper was cutting its workforce by 17 positions.

"These are always difficult decisions, so we will on occasion allow employees to volunteer for a severance package when we are reducing in areas where there are two or more of the same types of positions," Parrish said.

She added that if an employee in a group does not volunteer, "then the person with the least amount of tenure is included in the severance program."

Parrish declined further comment on personnel decisions.

Workplace experts said it?s practically unheard of for a company to take this approach when deciding who to terminate ? for good reason.

?I would strongly caution any organization from insourcing layoff decisions to the employees. There?s a reason why they pay people in leadership positions more than they pay their direct reports,? said Bob Kelleher, CEO of The Employee Engagement Group and author of the new book ?Creativeship: A Novel For Evolving Leaders.?

?Leaders should be held accountable for making those tough decisions,"?Kelleher said. "I don?t believe it should be the employees who are put in a position to make those decisions.?

Companies sometimes ask workers to step forward in a voluntary layoff situation, but pitting one person against another is not the way to go, said Nan Russell, host of the ?Work Matters? radio show and author of ?The Titleless Leader.??

?Personally, I think it?s very appalling that individuals would be in that kind of situation -- not only from the emotional standpoint for them to have to make that decision, but also for what happens to the people who are left behind and their now lack of respect for the leaders in that organization,? she said.

Management usually has guidelines when it comes to layoffs, whether the call is made based on performance or other factors, Russell said. Employees, in turn, expect that their leaders will make fair, tough decisions, and when they do, they earn workers? respect and trust.

But making two people choose who will be the one to leave indicates someone lacked the courage to make the choice, she added. That can create problems beyond the pain of the employees involved.

?Not only are they going to feel terrible no matter what the decision is, but the people left behind are, too, ?and are going to wonder what?s going to happen to them... .?Do you get chosen next?? Russell said.

Any action related to a layoff is always closely watched by the remaining employees, Kelleher said.?A?company always needs to evaluate what effect any decision will have on the individuals involved, as well as the organization and the brand, he said.

?Every action has a reaction,? Kelleher said.

Source: http://www.nbcnews.com/business/two-kansas-city-star-reporters-told-choose-who-gets-laid-1C7573609

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Wednesday, December 12, 2012

Media mogul and banker Allbritton dies at 87

WASHINGTON (Reuters) - Joe Lewis Allbritton, a media mogul and owner of the scandal-plagued Riggs National Bank, died on Wednesday at a hospital in Houston. He was 87.

Allbritton died of heart ailments, said Jerald Fritz, a senior vice president of Allbritton Communications.

Allbritton's media empire included newspapers throughout the U.S. Northeast and ABC network affiliates. Allbritton's son, Robert, recently founded the influential political publication Politico.

But Joe Allbritton, a Mississippi native, was famously known for owning and running Riggs, the Washington-based bank that had been a dominant force in diplomatic banking in the nation's capital.

Allbritton's banking career was tarnished when it was revealed that Riggs bank failed to report suspicious activity in the accounts held by former Chilean dictator Augusto Pinochet and Equatorial Guinea officials.

Riggs bank pleaded guilty in 2005 to violating anti-money laundering laws and was fined a total of $41 million.

Allbritton did not seek re-election to Riggs' board of directors and the storied bank was eventually acquired by PNC Financial Services.

Allbritton is survived by his wife, son and two grandchildren.

(Reporting By Rachelle Younglai; Editing by Eric Beech)

Source: http://news.yahoo.com/media-mogul-banker-allbritton-dies-87-020646326.html

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NKorea rocket a gift to leaders, warning to world

North Koreans toast after hearing the news of a rocket launch with beer at the newly-built Mansukyo Restaurant on Wednesday, Dec. 12, 2012 in Pyongyang, North Korea. North Korea appeared to successfully fire a long-range rocket Wednesday, defying international warnings as the regime of Kim Jong Un pushes forward with its quest to develop the technology needed to deliver a nuclear warhead. (AP Photo/Kim Kwang Hyon)

North Koreans toast after hearing the news of a rocket launch with beer at the newly-built Mansukyo Restaurant on Wednesday, Dec. 12, 2012 in Pyongyang, North Korea. North Korea appeared to successfully fire a long-range rocket Wednesday, defying international warnings as the regime of Kim Jong Un pushes forward with its quest to develop the technology needed to deliver a nuclear warhead. (AP Photo/Kim Kwang Hyon)

North Korean youths dance before the Pyongyang Grand Theatre in Pyongyang, North Korea, to celebrate a rocket launch on Wednesday, Dec. 12, 2012. North Korea appeared to successfully fire a long-range rocket Wednesday, defying international warnings as the regime of Kim Jong Un pushes forward with its quest to develop the technology needed to deliver a nuclear warhead. (AP Photo/Jon Chol Jin)

North Korean staff at the Three Revolution Exhibition Hall chat with one another inside the Satellite Hall after hearing the news of a rocket launch on Wednesday, Dec. 12, 2012 in Pyongyang, North Korea. North Korea appeared to successfully fire a long-range rocket Wednesday, defying international warnings as the regime of Kim Jong Un pushes forward with its quest to develop the technology needed to deliver a nuclear warhead. (AP Photo/Kim Kwang Hyon)

Why would North Korea launch a rocket into space now? The act invites additional sanctions for a country where the U.N. says millions are going hungry, and the bitter cold had only increased the risk of the launch becoming the latest of several embarrassing failures.

Some of Pyongyang's reasons are calendar-related: It's been 100 years since the birth of North Korea's founder, Kim Il Sung; nearly a year since the death of his son and successor, Kim Jong Il, and the first year in power for young leader Kim Jong Un. It's also a period of political transition for four countries with especially high stakes in the North: South Korea, the United States, China and Japan.

North Korea insists it launched a satellite Wednesday for peaceful purposes, but the act fits perfectly with its history of using carefully timed provocations to show the world it has dangerous toys and must be negotiated with. At home, the launch drums up North Korean unity and allows Pyongyang to cultivate an "us against them" mentality, part of the regime's survival strategy.

SENDING A MESSAGE

After lying low for several months, Pyongyang raised its "Remember me?" hand with an announcement about a December launch. It was issued just two days after South Korea aborted its own rocket launch, and four days after campaigning officially began in Seoul for the Dec. 19 elections that will usher in a new South Korean president.

The launch also sends a message to China, the U.S. and Japan, all focused on elections and assembling new governments, that they shouldn't keep North Korea, defiant even when it is needy, on the back burner for too long.

The launch is particularly complicated for China. Beijing remains North Korea's biggest ally and the linchpin to its economic survival, but Pyongyang has long shown it will do as it wishes.

North Korea announced the launch window just one day after Beijing sent an envoy to Pyongyang bearing a letter to Kim Jong Un from new leader Xi Jinping. "We are concerned," a Chinese Foreign Ministry spokesman said after the announcement, without clarifying whether the issue came up for discussion in Pyongyang.

Japan holds elections on Dec. 16, and newly re-elected President Barack Obama will be inaugurated to a second term in a few weeks. With the South Korean president taking office in February, it could be months before the region is ready to rethink North Korea policy.

CELEBRATING A CENTENARY

North Korea also has domestic reasons for justifying a rocket launch before the year's end.

Nearly four years ago, the regime in Pyongyang set an ambitious goal for its people: to "open the gate to becoming a strong and prosperous nation in 2012" ? the year that North Korea founder Kim Il Sung would have turned 100.

The economy, science and technology were pinpointed as three areas of focus after decades of lagging behind its fast-developing neighbors. Decrepit shops were torn down to make way for cavernous supermarkets stocked with flat-screen TVs and Coca-Cola. The State Academy of Sciences sent scholars abroad to study the latest agricultural techniques. Kim Jong Il sent HP and Dell computers to the nation's top universities.

Schoolchildren from Samjiyon in the far north to Kaesong near the border with South Korea began learning about North Korea's ambitious space and nuclear programs. Students painted satellites on classroom walls, and playgrounds were installed with miniature rockets instead of slides.

In April 2009, North Korean scientists tested a three-stage rocket from an east coast launch pad. This year, two days before Kim Il Sung's April 15 birthday, scientists attempted to launch a rocket from a new launch pad on the west coast, but it broke up just 90 seconds after liftoff.

North Koreans treated it as a celebration, anyway. Pyongyang residents were sanguine about the failure, noting that China and Russia struggled with their rockets, too, before reaching space. The failure and ensuing global condemnation did little to dampen festivities, and the city went ahead with a massive birthday fireworks show over the Taedong River.

MOURNING KIM JONG IL

If the April launch attempt was seen as a gift to Kim Il Sung, the December success may be an homage to Kim Jong Il.

Kim, who ruled for 17 years under a "military first" policy before his Dec. 17, 2011, death, made getting a satellite into space one of the last goals of his leadership. In his honor, North Korea's three satellites have been dubbed "Kwangmyongsong," or Lode Star, in honor of the bright star that legendarily appeared in the skies when Kim was born.

Two weeks before the first anniversary of his death, North Korea has already quieted down amid an unofficial state of mourning. State media are churning out odes to the late leader, honoring everything from his skill as a composer to the workaday parka he famously wore while making "on the spot" field trips by train.

A grand commemoration can be expected to mark Kim's death, and a rocket mounted with at satellite named after the Dear Leader could end up being the biggest firework of them all.

ELEVATING KIM JONG UN

Outside observers consider Wednesday's liftoff North Korea's first successful satellite launch, and although North Korea had claimed the 2009 launch was also successful, this certainly boosts the standing of Kim Jong Un.

Though omnipresent now, he had been a mystery when he was revealed several years ago as the heir-apparent. One of Kim Jong Un's early tasks as successor-in-training was to oversee the launch of the April 2009 rocket, which he monitored from the command center.

Throughout his succession campaign and during this first year of leadership, the 29-year-old has been characterized by state propaganda as young, modern, tech-savvy and forward-thinking. He has been working to build a base of loyalty among North Koreans struggling with chronic economic hardship by promising them a higher standard of living and a better future. The rocket and satellite are portrayed by state media as a symbol of the nation's future.

SATELLITE OR MISSILE?

Washington, Seoul and other adversaries see a more sinister objective in the launch.

Experts note that sending a satellite into space uses a similar technology as firing a long-range missile capable of striking American soil. The U.N. Security Council warns that a North Korean rocket fired for civilian purposes or otherwise would violate a ban on developing its missile and nuclear programs. The Security Council, which has already passed two rounds of sanctions, was to meet behind closed doors Wednesday to discuss its response to the launch.

The North Koreans are not naive about the distinction between satellite launches and missiles. They see their nukes as a bulwark against U.S. military might in the region. The 2009 rocket launch was followed within weeks by another, more worrying test: a nuclear bomb.

With a successful rocket launch, the U.S. and other countries fear North Korea's next step will be to master miniaturization technology so their nukes are small enough to be loaded onto missiles.

Pyongyang's position to Washington: Sign a peace treaty and withdraw your troops from South Korea, and then maybe we'll get rid of our bombs.

___

Jean H. Lee divides her time between Pyongyang, North Korea, and Seoul, South Korea, as AP's Korea bureau chief. Follow her on Twitter at www.twitter.com/newsjean.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-12-12-NKorea-Rocket%20Launch-Why%20Now?/id-701e94ffed7b4b4aacc2d0fad9bcde9e

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